The Surprising Brain Exercise That Reverses Aging

Reversing a Decade of Brain Aging

A clinical trial led by McGill University has become the first in humans to demonstrate that online brain training can strengthen the brain networks involved in learning and memory.

In the study, older adults who used the game-like app BrainHQ for 10 weeks showed improved cholinergic function, a chemical system in the brain that tends to decline with age and plays a central role in attention, memory, and decision-making.

“The training restored cholinergic health to levels typically seen in someone 10 years younger,” said senior author Dr. Etienne de Villers-Sidani, an Associate Professor in McGill’s Department of Neurology and Neurosurgery and neurologist at The Neuro (Montreal Neurological Institute-Hospital).

“This is the first time any intervention, drug or non-drug, has been shown to do that in humans,” he said.

Because Alzheimer’s disease is marked by steep declines in cholinergic function, the results help explain earlier research suggesting that these types of cognitive exercises may lower dementia risk and improve mental performance. The researchers note that this approach could serve as a safer option than medication or work in combination with it.

How BrainHQ Sharpens the Mind

BrainHQ features speed-based cognitive exercises that increase in difficulty as users improve, a design supported by hundreds of previous studies.

“A lot of people assume crossword puzzles or reading are enough to keep the brain sharp. But not all activities truly promote neuroplasticity,” said de Villers-Sidani.

Since BrainHQ is already available to the public, clinicians can discuss it with patients who are interested in maintaining or enhancing their cognitive health, he added.